Forensic / Toxicology Group 2

CO poisoning
what is the anti-dote

is there any role for hyperbaric oxygen

how does CO poisoning cause hypoxia

what is the characteristic skin color of a pt suffering from CO poisoning?? The answer is “RED”, and the doctor then asked about the causes of this redness of skin, and the causes of absence of cyanosis in CO poisoning


Methanol
What are the antidotes of methanol?? The answer was : ethanol and fomepizole (4-MP), and then the doctor asked weather we can give ethanol and 4-MP together or not, and the answer was NO,WE CAN’T, since fomepizole will inhibit the action of ethanol as an antidote of methanol, rendering ethanol administration useless!! (the answer can be easily understood when you study the topic of alcohols and glycols).

you have 2 patients who have drunk the same amount of methanol and then both suffered from symptoms of methanol poisoning and were brought to the ER. You asked for blood levels of methanol, and the results showed that one of them has high methanol conc. In blood, while the other has a low conc. Which one of them you will consider his situation to be worse?
The answer was “ THE ONE WITH LOW METHANOL CONCENTRATION IN BLOOD”. The explanation of this answer lies in the fact that having low methanol concentration in blood means that most of the dose taken was metabolized, and the cause of toxicity in methanol poisoning is the metabolites, NOT methanol itself!! So having low methanol conc. In the case above Means having more metabolites ( since the same dose was taken by the 2 patients), and this in turn means a worse condition!


several questions about “activated charcoal”, mainly about it’s mechanism of action

Mention 3 CNS stimulants. How does cocaine work

Acetaminophen
pathophysiology of poisoning
antidote (NAC), and how does it work